Homologous Superfamily

Ubiquitin-activating enzyme E1, SCCH domain (IPR042063)

Short name: Ubi_acti_E1_SCCH

Overlapping entries


This superfamily represents the domain 5 found in Ubiquitin-activating enzyme E1. There are several homologues of this enzyme with one of them being ThiF [PMID: 19089947].

The E1 enzyme that catalyzes carboxy-terminal Ub adenylation, thioester bond formation to a catalytic cysteine in the E1 Cys domain, together with thioester transfer to a catalytic cysteine in E2 conjugating enzymes are responsible for the Ubiquitin (Ub) conjugation initiation [PMID: 23416107].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.