ING2, PHD domain (IPR042019)

Short name: ING2_PHD

Overlapping homologous superfamilies

Domain relationships


This entry represents the PHD domain of ING2.

Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 [PMID: 11481424]. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [PMID: 16387653, PMID: 20676127]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [PMID: 12859901, PMID: 23823870].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.