Domain

Nicotinate/nicotinamide phosphoribosyltransferase (IPR041525)

Short name: N/Namide_PRibTrfase

Overlapping homologous superfamilies

Domain relationships

None.

Description

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis [PMID: 18490451]. Members in this family can be split into two further subfamilies represented in IPR006405 and IPR006406. Members in IPR006405 have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. However, one argument suggesting that this family represents the same enzyme is that no species has a member of both subfamilies. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria.

Nicotinamide phosphoribosyl transferase (NAMPT) catalyses the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD [PMID: 19149599, PMID: 19109034]. NAMPT is also known as pre-B cell colony-enhancing factor (PBEF) or visfatin.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam