Domain

NLRC5, atypical caspase recruitment domain (IPR041210)

Short name: NLRC5_atypical_Card

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. It possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD [PMID: 24815518].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam