Domain

Sorting nexin-17/31, FERM domain (IPR040842)

Short name: SNX17/31_FERM

Overlapping homologous superfamilies

Domain relationships

Description

This domain can be found at C terminus of sorting nexin 17 (SNX17) and sorting nexin 31 (SNX31). SNX17 localizes to early endosomes where it directly binds NPX(Y/F) motifs in the target receptors to mediate their rates of endocytic internalization, recycling, or degradation. The domain is known as terminal band 4.1/ezrin/radixin/moesin (FERM) domain. The FERM domain binds directly to the common motif, NPX(Y/F), in the cytoplasmic region of its target proteins [PMID: 23382219].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam