Domain

TIAM1, CC-Ex domain (IPR040655)

Short name: TIAM1_CC-Ex

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Tiam1 is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration [PMID: 20361982, PMID: 26887924]. Tiam1 is involved in multiple steps of tumorigenesis [PMID: 24308970].

This entry represents the CC and Ex subdomain found in the PH-CC-Ex globular domain of the Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long alpha-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three alpha-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH subdomain through a four-residue linker [PMID: 19893486].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam