Family

WD repeat-containing protein 19/dyf-2 (IPR040379)

Short name: WDR19/dyf-2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Proteins in this entry contain WD40 repeats, and include WD repeat-containing proteins 19 (WDR19), from mammals, and dyf-2 from nematodes. Both WDR19 and dyf-2 are components of the IFT complex A (IFT-A), which is required for retrograde ciliary transport [PMID: 20889716, PMID: 28479320]. Mutations in the WDR19 gene are associated with numerous diseases, including cranioectodermal dysplasia 4, short-rib thoracic dysplasia 5 with or without polydactyly, nephronophthisis 13 [PMID: 22019273], and Senior-Loken syndrome 8 [PMID: 23683095].

GO terms

Biological Process

GO:0035721 intraciliary retrograde transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER