Mitochondrial carrier domain protein (IPR040062)

Short name: Mitochondrial_carrier_protein

Overlapping homologous superfamilies

Family relationships


Proteins in this family contain a mitochondrial carrier domain. Proteins include:

  • Mitochondrial glycine transporter (HEM25), which imports glycine into the mitochondrial matrix, which is imprtant for heme biosynthesis [PMID: 27476175].
  • Mitochondrial thiamine pyrophosphate carrier 1 (TPC1), which imports thiamine pyrophosphate into the mitochondrion [PMID: 12411483].
  • Mitochondrial brown fat uncoupling protein 1 (UCP1), which is important for thermogenic respiration. TPC1 imports a long-chain fatty acid and a proton into the inner mitochondrial membrane. The import of protons dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP [PMID: 24196960]
  • Mitochondrial uncoupling proteins 2 (UCP2) and 3 (UCP3), which are important for generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical gradient across the inner mitochondrial membrane in brown adipose tissue [PMID: 9054939].
  • Phosphate carrier protein, mitochondrial (SLC25A3), which transports phosphate groups from the cytosol to the mitochondrial matrix [PMID: 8144629].
Homologues are predominantly from eukaryotes.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.