Domain

Diguanylate cyclase DosC, globin sensor domain (IPR039435)

Short name: DosC_GS

Overlapping homologous superfamilies

Domain relationships

None.

Description

Proteins containing this domain have a C-terminal diguanylate cyclase (DGC/GGDEF) domain coupled to the globin sensor domain. DGC/GGDEF likely functions as a c-di-GMP cyclase in the synthesis of the second messenger cyclic-di-GMP (c-di-GMP). Members include Escherichia coli DosC (also known as YddV), the gene for which is found in a two-gene operon, dosCP. In DosC, the sensory globin domain is coupled to a GGDEF-class diguanylate cyclase, while in DosP, a heme-containing PAS domain is coupled to an EAL-class c-di-GMP phosphodiesterase [PMID: 26148715]. DosP and DosC associate in a di-GMP-responsive Escherichia coli RNA processing complex along with polynucleotide phosphorylase (PNPase), enolase, RNase E, and RNA [PMID: 19764732].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD