Epsin, ENTH domain (IPR039416)

Short name: Epsin_ENTH

Overlapping homologous superfamilies

Domain relationships

  • ENTH domain (IPR013809)
    • Epsin, ENTH domain (IPR039416)


The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis [PMID: 11911874]. A set of proteins previously designated as harbouring an ENTH domain in fact contains a highly similar, yet unique module referred to as an AP180 N-terminal homology (ANTH) domain. ENTH and ANTH (E/ANTH) domains are structurally similar to the VHS domain and are composed of a superhelix of eight alpha helices [PMID: 12740367].

E/ANTH domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles [PMID: 15890985, PMID: 16231097]. E/ANTH-bearing proteins have been shown to function with adaptor protein-1 and GGA adaptors at the trans-Golgi network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding [PMID: 12742163].

Epsins play an important role as accessory proteins in clathrin-mediated endocytosis [PMID: 17276129, PMID: 12353027].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.