RagC/D (IPR039400)

Short name: RagC/D

Overlapping homologous superfamilies

Family relationships


RagC and RagD are closely related Rag GTPases (ras-related GTP-binding protein C and D) that constitute a unique subgroup of the Ras superfamily [PMID: 15731001], and are functional homologues of Saccharomyces cerevisiae Gtr2. They form heterodimers with RagA or RagB [PMID: 11073942], and similarly, Gtr2 dimerizes with Gtr1 in order to function. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling [PMID: 20381137], exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7 [PMID: 20381137].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.