Domain

Homoaconitase, swivel domain (IPR039386)

Short name: Homoaconitase_swivel

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the swivel domain found in homoaconitase and other uncharacterized proteins of the aconitase family [PMID: 9020582]. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized via the alpha-aminoadipate pathway. In this pathway, homoaconitase catalyzes the conversion of cis-homoaconitic acid into homoisocitric acid. The reaction mechanism is believed to be similar to that of other aconitases. The swivel domain is believed to undergo swivelling conformational change in the enzyme mechanism [PMID: 7675781, PMID: 14568143].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD