Family

CREBL2/REPTOR-BP (IPR039250)

Short name: CREBL2/REPTOR-BP

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The cAMP-responsive element-binding protein-like 2 (CREBL2) is an uncharacterized protein containing a basic-leucine zipper (bZip) domain. Because of the location of the gene in a region frequently deleted in cancers, it has been suggested that CREBL2 is a tumour repressor [PMID: 9693048].

This entry also includes REPTOR-BP from fruit flies. It is a transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation [PMID: 25920570].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER