Peroxisomal/glyoxysomal leader peptide-processing protease (IPR039245)

Short name: TYSND1/DEG15

Overlapping homologous superfamilies


Family relationships

  • Peroxisomal/glyoxysomal leader peptide-processing protease (IPR039245)


The peroxisomal leader peptide-processing protease (TYSND1, trypsin domain-containing 1) removes the N-terminal transit peptide from proteins containing a PTS2 target sequence [PMID: 22002062]. The plant glyoxysomal processing protease (DEG15) performs a similar function in the glyoxysome, a specialized peroxisome. DEG15 exists as a homodimer or as a monomer; as a dimer it is a processing enzyme, as a monomer it degrades denatured proteins [PMID: 17592111]. These peptidases are trypsin homologues and members of MEROPS family S1 and subfamily S1B. Cleavage requires a cysteine residue in P1 or P2 [PMID: 17592111].

GO terms

Biological Process

GO:0016485 protein processing

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0005777 peroxisome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.