Protein FAM3D (IPR039240)

Short name: FAM3D

Overlapping homologous superfamilies


Family relationships


FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling. As dysregulated glucagon secretion is a characteristic of type 2 diabetes, FAM3D could have a therapeutic potential [PMID: 28247283]. FAM3D is constitutively expressed in the gastrointestinal tract [PMID: 22226334] and could play a role in gastrointestinal homeostasis and inflammation through its receptors FPR1 and FPR2 [PMID: 26966188].

GO terms

Biological Process

GO:0070093 negative regulation of glucagon secretion

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.