Coiled-coil domain-containing protein 66 (IPR039183)

Short name: CCD66

Overlapping homologous superfamilies


Family relationships



CCDC66 localizes to the centrosome and the centriolar satellites [PMID: 28235840]. It interacts with CEP290 and functions in cilium formation and trafficking. It has also been shown to bind to microtubules in vitro and in vivo [PMID: 28235840]. Mutations of the CCD66 gene in dogs cause progressive retinal atrophy [PMID: 19777273]. Homologues are found only in metazoa.

GO terms

Biological Process

GO:0046548 retinal rod cell development

Molecular Function

GO:0008017 microtubule binding

Cellular Component

GO:0005813 centrosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.