Osteocalcin (IPR039176)

Short name: Osteocalcin

Overlapping homologous superfamilies


Family relationships


Bone gamma-carboxyglutamic acid protein (BGP), also known as osteocalcin, is a calcium-binding bone matrix protein that contains the vitamin-K-dependent amino acid, gamma-carboxyglutamic acid. It is a noncollagen proteins made in osteoblasts and odontoblasts and has been linked to bone formation. It may also act as a hormone to affect insulin sensitivity and energy expenditure; however, only the undercarboxylated form of osteocalcin is active [PMID: 23147574].

GO terms

Biological Process

GO:0060348 bone development
GO:1900076 regulation of cellular response to insulin stimulus
GO:0032571 response to vitamin K

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.