Family

Glucokinase, chordate (IPR039073)

Short name: GCK_chordate

Overlapping homologous superfamilies

None.

Family relationships

  • Hexokinase (IPR001312)
    • Glucokinase, chordate (IPR039073)

Description

This entry represents glucokinase (EC EC:2.7.1.2; also known as hexokinase type IV) from chordates. Glucokinase is highly specific for glucose and phosphorylates glucose using ATP as a donor to produce glucose-6-phosphate and ADP [PMID: 9023215]. In the pancreas, glucokinase has an important role in insulin secretion and various natural mutations can cause diabetes melitis [PMID: 25015100].

GO terms

Biological Process

GO:0032024 positive regulation of insulin secretion

Molecular Function

GO:0004340 glucokinase activity
GO:0005536 glucose binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER