Serine/threonine-protein kinase RAC gamma-like (IPR039029)

Short name: RAC_gamma-like

Overlapping homologous superfamilies

Family relationships



Protein kinase B (PKB), also called Akt or RAC, is a phosphatidylinositol 3'-kinase (PI3K)-dependent Ser/Thr kinase which alters the activity of the targeted protein [PMID: 12545728]. Akt regulates numerous cellular processes, including cell growth, differentiation, proliferation, apoptosis, and glucose metabolism. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues [PMID: 12431841, PMID: 28431241]. Human Akt has three isoforms derived for distinct genes: Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma.

This entry represents Akt3 from mammals and related proteins. Akt3 inhibits adipogenesis via WNK1/SGK1 signaling [PMID: 29202451]. It is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal brain size [PMID: 15713641]. This entry also includes Akt2 from Caenorhabditis elegans [PMID: 9716402].

GO terms

Biological Process

GO:0035556 intracellular signal transduction

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.