Pre-mRNA-processing factor 19 (IPR038959)

Short name: Prp19

Overlapping homologous superfamilies

Family relationships



This family includes Pre-mRNA-processing factor 19 (Prp19) and its homologues. Prp19 is an ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR) [PMID: 24332808]. Human Prp19 is part of the nineteen complex (NTC), which acts as a multimeric E3 ubiquitin ligase in DNA repair and splicing. Prp19 forms a homotetramer and is an autoinhibited E3 ubiquitin ligase; its activation requires its interaction with splicing factors SPF27, CDC5L, and PLRG1 [PMID: 29547724].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0000398 mRNA splicing, via spliceosome

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

GO:0000974 Prp19 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.