Family

Sodium channel and clathrin linker 1 (IPR038911)

Short name: SCLT1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Sodium channel and clathrin linker 1 (SCLT1/CAP-1A) is an adapter protein that links clathrin and sodium channel Na(v)1.8. It may regulate Na(v)1.8 channel density at the cell surface [PMID: 15797711]. SCLT1 is a component of the distal appendages (DAPs) of centrioles, which are thought to anchor cilia to the plasma membrane [PMID: 23348840]. SCLT1 mutations are associated with the ciliopathy known as oral-facial-digital syndrome (OFD) [PMID: 28486600, PMID: 24285566].

GO terms

Biological Process

GO:0045162 clustering of voltage-gated sodium channels

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER