Integrator complex subunit 1 (IPR038902)

Short name: INTS1

Overlapping homologous superfamilies


Family relationships



INTS1 is a component of the Integrator (INT) complex. INT consists of at least 14 subunits and associates with the C-terminal domain of the largest subunit of the RNA polymerase II (RNAPII) and has a role in the regulation of gene expression and RNA processing. Besides mediating the co-transcriptional 3'-end processing of the U-rich small nuclear RNAs (UsnRNAs), INT also functions in RNAPII promoter proximal pause-release and in the processing of enhancer RNAs. Mutations in the INTS1 gene cause a severe neurodevelopmental syndrome [PMID: 28542170].

GO terms

Biological Process

GO:0034474 U2 snRNA 3'-end processing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032039 integrator complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.