Family

E3 ubiquitin-protein ligase RNF170 (IPR038896)

Short name: RNF170

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

RNF170 is an endoplasmic reticulum membrane ubiquitin ligase that contributes to the ubiquitination of activated inositol 1,4,5-trisphosphate (IP3) receptors. When point mutated (arginine to cysteine at position 199), it causes autosomal dominant sensory ataxia (ADSA), a disease characterised by neurodegeneration in the posterior columns of the spinal cord [PMID: 25882839].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER