Dehydrodolichyl diphosphate synthase complex subunit Nus1 (IPR038887)

Short name: Nus1/NgBR

Overlapping homologous superfamilies

Family relationships



Nus1 (also known as Nogo-B receptor, NgBR) is a subunit of cis-prenyltransferase, a enzymatic activity critical for the synthesis of dolichol, an obligate carrier of oligosaccharides for protein glycosylation reactions [PMID: 25066056]. It plays an essential role in angiogenesis during wound healing and embryonic development. In mice, it is essential for endothelial cell glycosylation and vascular development [PMID: 26755743]. In zebrafish, it is bound by Nogo-B ligand that activates Akt pathway to stimulate endothelial cell chemotaxis [PMID: 20813898]. In humans, it is involved in breast cancer cell growth through modulating Ras signaling [PMID: 29346419].

GO terms

Biological Process

GO:0001525 angiogenesis
GO:0019408 dolichol biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:1904423 dehydrodolichyl diphosphate synthase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.