Family

Mitogen-activated protein kinase 13 (IPR038785)

Short name: p38delta

Overlapping homologous superfamilies

Family relationships

Description

p38 kinases are mitogen-activated protein kinases (MAPKs), which serve as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines [PMID: 23954936].

Vertebrates contain four p38 kinases, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns.

p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine [PMID: 20090411]. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest [PMID: 12713588]. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main kinase involved in regulating the differentiation and apoptosis of keratinocytes [PMID: 12810719].

GO terms

Biological Process

GO:0000165 MAPK cascade

Molecular Function

GO:0004707 MAP kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD