Family

Splicing factor 3B subunit 1-like (IPR038737)

Short name: SF3b_su1-like

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes animal splicing factor 3B subunit 1 (SF3B1, also known as SAP 155) and its homologues such as Hsh155 from budding yeasts [PMID: 10688664] and Prp10 from fission yeasts [PMID: 9837997]. SF3B1 is a component of the splicing factor SF3B complex, which is important for anchoring the spliceosome to precursor mRNA. SF3B1 binds to pre-mRNA on both sides of the intron branch site region [PMID: 11500380]. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly [PMID: 16432215].

GO terms

Biological Process

GO:0000245 spliceosomal complex assembly

Molecular Function

GO:0003729 mRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER