Homologous Superfamily

SNF2-like, N-terminal domain superfamily (IPR038718)

Short name: SNF2-like_sf

Overlapping entries

Description

This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, MOT1), DNA repair (e.g., RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information [PMID: 7651832, PMID: 14729263]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.

Proteins that contain this domain appear to be distantly related to the DEAX box helicases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D