Homologous Superfamily

RNA polymerase sigma-54 factor, core-binding domain superfamily (IPR038709)

Short name: RpoN_core-bd_sf

Overlapping entries


Bacterial core RNA polymerases (with subunit composition alpha2-beta-beta') must combine with a sigma subunit to transcribe from specific DNA promoter sequences. This domain, found in sigma factor 54, makes a direct interaction with the core RNA polymerase to form an enhancer dependent holoenzyme [PMID: 10894718]. The centre of this domain contains a very weak similarity to a helix-turn-helix motif, which may represent a DNA binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.