Homologous Superfamily

TNFAIP8 superfamily (IPR038355)

Short name: TNFAIP8_sf

Overlapping entries


Four tumor necrosis factor alpha-induced protein 8-like proteins have been identified: TNFAIP8 (also known as TIPE), TIPE1, TIPE2 and TIPE3. Overexpressed TIPE in cells can reduce cell death in vitro and increase tumor growth in vivo [PMID: 10644768]. By contrast, TIPE2 has been demonstrated to be an inhibitor of Ras and to have a pro-apoptotic ability. TIPE1 could upregulate the pro-apoptotic members of the B-cell leukemia/lymphoma (Bcl)-2 family of proteins [PMID: 27900028].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.