Homologous Superfamily

Stn1, C-terminal domain superfamily (IPR038240)

Short name: Stn1_C_sf

Overlapping entries


Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [PMID: 17715303]. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [PMID: 17293872].

This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [PMID: 19884503].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.