Homologous Superfamily

Vps16, C-terminal domain superfamily (IPR038132)

Short name: Vps16_C_sf

Overlapping entries


Vps16 forms part of the Class C vacuolar protein sorting (Vps) complex. It is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [PMID: 11702788]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [PMID: 11422941]. The role of VPS16 in this complex is not known.

The C-terminal domain of Vps16 binds to Vps33 for integration into the HOPS complex [PMID: 23840694].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.