Homologous Superfamily

Cell division control protein 73, C-terminal domain superfamily (IPR038103)

Short name: CDC73_C_sf

Overlapping entries


CDC73 is an RNA polymerase II accessory factor [PMID: 8812838], and forms part of the Paf1 complex that has roles in post-initiation events [PMID: 9032243]. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase [PMID: 9891041].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.