Homologous Superfamily

Nucleophosmin, C-terminal domain superfamily (IPR038101)

Short name: NPM1_C_sf

Overlapping entries


This superfamily represents a domain, approximately 50 residues in length, mainly found in C-terminal region of nucleophosmin from animals [PMID: 16794633]. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli [PMID: 16794633]. Although it shuttles rapidly between the nucleus and the cytoplasm, a large fraction of NPM1/B23 resides in the nucleoli [PMID: 16041368]. Mutations of the NPM1 gene has been linked to acute myeloid leukemia [PMID: 22707729].

The structure of this domain has a three-helix bundle which binds the G-quadruplex DNA at the interface between helices H1 and H2 through electrostatic interactions with the G-quadruplex phosphate backbone [PMID: 22707729, PMID: 24952945].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.