Family

E3 ubiquitin-protein ligase RING1 (IPR038036)

Short name: RING1

Overlapping homologous superfamilies

None.

Family relationships

Description

E3 ubiquitin-protein ligase RING1 (EC:2.3.2.27) is one three E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, which is a specific tag for repression of epigenetic transcription and particularly for inactivation of chromosome X of female mammals [PMID: 16359901, PMID: 15525528]. RING1 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, the repressive BCOR complex [PMID: 16943429], and the the E2F6.com-1 complex in G0 phase [PMID: 12004135]. RING1 has a RING-type zinc finger.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0035102 PRC1 complex
GO:0031519 PcG protein complex
GO:0000151 ubiquitin ligase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER