Family

Chromobox protein homologue 3 (IPR038033)

Short name: CBX3

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Chromobox protein homologue 3 (CBX3, also known as HP1 gamma) is a component of heterochromatin that binds histone H3 tails methylated at 'Lys-9' which leads to epigenetic repression [PMID: 11242053]. By interacting with MIS12 complex, it is involved in the formation of a functional kinetochore [PMID: 15502821]. It recruits NIPBL to sites of DNA damage at double-strand breaks [PMID: 28167679]. It is a component of the E2F6.com-1 [PMID: 12004135] and PER [PMID: 24413057] complexes. The PER complex controls the circadian clock [PMID: 24413057].

GO terms

Biological Process

GO:0045892 negative regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005719 nuclear euchromatin

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER