Domain

ASAP1, SH3 domain (IPR038016)

Short name: ASAP1_SH3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • ASAP1, SH3 domain (IPR038016)

Description

ASAPs (ASAP1, ASAP2, and ASAP3) function as Arf-specific GTPase-activating proteins (GAPs), participate in rhodopsin trafficking, are associated with tumor cell metastasis, modulate phagocytosis, promote cell proliferation, facilitate vesicle budding, Golgi exocytosis, and regulate vesicle coat assembly via a Bin/Amphiphysin/Rvs domain [PMID: 10725410, PMID: 21775626, PMID: 18400762]. Each member has a BAR, PH, Arf GAP, Ank repeat and proline rich domains. ASAP1 and ASAP2 also have a SH3 domain at the C terminus [PMID: 18675341]. ASAP1 has been implicated in regulating cell motility and invasion [PMID: 20154719].

This entry represents the SH3 domain of ASAP1.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD