RBP-Jkappa, IPT domain (IPR038007)

Short name: RBP-Jkappa_IPT

Overlapping homologous superfamilies

Domain relationships



This entry represents the IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa, also known as RBP-J). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes. Later, its was found to be a transcriptional regulator downstream of Notch receptors [PMID: 12374742,PMID: 12548545, PMID: 21991380].

IPT/TIG (immunoglobulin, plexin, transcription factor-like/transcription factor immunoglobulin) domains adopt an immunoglobulin-like fold and have been found in proteins involved in transcriptional regulation and signal transduction, and can also participate in protein-protein interactions [PMID: 23477311].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.