Transcriptional regulatory protein Sin3a (IPR037969)

Short name: SIN3A

Overlapping homologous superfamilies


Family relationships


Sin3a is a transcriptional repressor and a homologue of the SIN3 repressor from yeast. Sin3a associates with the strong repressive isoform of Mxi1, a helix-loop-helix leucone zipper that associates with Max to antagonize Myc oncogenic activities [PMID: 8649810]. Unlike Mxi1 and Myc, expression of Sin3a does not vary during development [PMID: 8649810]. Sin3a is a component of several complexes, including the REST-CoREST repressor complex [PMID: 10734093], the PER complex which maintains circadian rhythm [PMID: 21680841] and the Sin3 HDAC complex [PMID: 12724404]. Sin3a also interacts with FOXK1 to regulate cell cycle progression [PMID: 22476904]. Sin3a has three PAH domains by which it interacts with HCFC1, REST and SAP30 [PMID: 10734093,PMID: 9702189].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003714 transcription corepressor activity

Cellular Component

GO:0016580 Sin3 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.