Apoptotic Protease-Activating Factor 1, CARD domain (IPR037963)

Short name: APAF1_CARD_dom

Overlapping homologous superfamilies

Domain relationships

  • CARD domain (IPR001315)
    • Apoptotic Protease-Activating Factor 1, CARD domain (IPR037963)


Apoptotic protease activating factor-1 (Apaf-1) is a component protein of the apoptosome [PMID: 24651435]. During apoptosis, cytochrome c is released from mitochondria to the cytosol and binds Apaf-1. Binding of cytochrome c to Apaf-1 allows the recruitment and activation of caspase-9 within the apoptosome [PMID: 18439902].

This entry represents the CARD domain of Apaf-1. CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms [PMID: 17408690, PMID: 10578182].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.