Inactive histone-lysine N-methyltransferase 2E (IPR037955)

Short name: KMT2E

Overlapping homologous superfamilies


Family relationships



The protein known as histone-lysine N-methyltransferase 2E (KMT2E, mixed-lineage leukemia 5 or MLL5) has been shown to lack key residues and an essential loop in the the SET-I subdomain required for binding substrate and cofactors [PMID: 27812132]. MLL5 had been thought to be specific for mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2; which are specific tags for epigenetic transcriptional activation), and a component of an MLL5 complex, but the paper describing this alleged complex has been retracted by the authors [PMID: 15199122]. MLL5 mediates hematopoietic cell homeostasis, spermatogenesis, cell cycle progression, and survival [PMID: 23798402, PMID: 27812132]. It is recruited to gene-rich euchromatic regions via the interaction of its plant homeodomain finger with the histone mark H3K4me3 [PMID: 23798402]. Overexpression of the MLL5 gene induced cell cycle arrest in G(1) phase [PMID: 14718661].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.