Sentrin-specific protease 3 (IPR037945)

Short name: SENP3

Overlapping homologous superfamilies


Family relationships



Sentrin-specific protease 3 (SENP3, MEROPS identifier C48.003) is an isopeptidase that releases SUMO2 and SUMO3 monomers from sumoylated substrates by hydrolysing the isopeptide bond [PMID: 16608850]. SENP3 is a cysteine peptidase with a fold similar to that of adenain, and has the catalytic triad His, Asp, Cys, the reverse of the order in papain. Among the proteins that are deconjugated by SENP3 are MEF2D [PMID: 15743823], CDCA8 [PMID: 18946085], EP300 [PMID: 19680224], and nucleophosmin [PMID: 18259216]. SENP3 is a component of the 5FMC [PMID: 22872859] and MLL1/MLL complexes [PMID: 15960975].

GO terms

Biological Process

GO:0016926 protein desumoylation

Molecular Function

GO:0008234 cysteine-type peptidase activity

Cellular Component

GO:0071339 MLL1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.