E3 ubiquitin-protein ligase MSL2 (IPR037922)

Short name: MSL2

Overlapping homologous superfamilies


Family relationships



E3 ubiquitin-protein ligase MSL2 (MSL2; EC:6.3.2.-) is an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. It is a component of MSL complex [PMID: 23084835].

The male-specific lethal (MSL) complex is a histone acetyltransferase with specificity for histone H4 'lysine-16' in chromatin. The complex consists of MOF, MSL1, MSL2, and MSL3 [PMID: 16227571]. The complex was first identified in Drosophila.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

GO:0072487 MSL complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.