Domain

Cytochrome b5 reductase 4, p23 domain (IPR037908)

Short name: p23_NCB5OR

Overlapping homologous superfamilies

Domain relationships

  • CS domain (IPR007052)
    • Cytochrome b5 reductase 4, p23 domain (IPR037908)

Description

NAD(P)H cytochrome b5 oxidoreductase (NCB5OR) is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum) [PMID: 10611283, PMID: 15131110]. It appears to play a critical role in maintaining viable pancreatic beta cells [PMID: 16814408]. Mice homozygous for a targeted knockout (KO) of the gene encoding NCB5OR develop an early-onset nonautoimmune diabetes phenotype with a non-inflammatory beta-cell deficiency. The role of NCB5OR in beta cells may be in maintaining or regulating their redox status [PMID: 21839170]. The gene encoding NCB5OR has been considered as a positional candidate for type II diabetes and other diabetes subtypes related to B-cell dysfunction; however, variation in its coding region does not appear not to be a major contributor to the pathogenesis of these diseases [PMID: 15504981].

This entry represents the CS p23-like domain found in NCB5OR. In addition to a p23-like domain NCB5OR contains an N-terminal cytochrome b5 domain and a C-terminal cytochrome b5 oxidoreductase domain [PMID: 20630863].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD