Pathways & interactions
MONaKA, PX domain (IPR037903)
Short name: MONaKA_PX
Overlapping homologous superfamilies
- PX domain superfamily (IPR036871)
- Phox homologous domain (IPR001683)
- MONaKA, PX domain (IPR037903)
MONaKA (Modulator of Na,K-ATPase), also known as PXK, binds the plasma membrane ion transporter, Na,K-ATPase, and modulates its enzymatic and ion pump activities. It modulates brain Na,K-ATPase and may be involved in regulating electrical excitability and synaptic transmission [PMID: 16135750]. MONaKA contains an N-terminal PX domain and a C-terminal kinase domain that lacks several residues necessary for intrinsic catalytic activity [PMID: 16142408]. This entry represents the PX domain of MONaKA.
In general, the PX domain interacts with PIs and plays a role in targeting proteins to PI-enriched membranes [PMID: 16782399].
- cd06871 (PX_MONaKA)