Calcyclin-binding Protein, CS domain (IPR037893)

Short name: CS_CacyBP

Overlapping homologous superfamilies

Domain relationships

  • CS domain (IPR007052)
    • Calcyclin-binding Protein, CS domain (IPR037893)


This CS p23-like domain is found in the CacyBP/SIP protein (S100A6 binding protein and Siah-1 interacting protein) [PMID: 15996101]. CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1 [PMID: 17916393]. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells [PMID: 20182755]. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development [PMID: 18171983].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0044548 S100 protein binding
GO:0015631 tubulin binding
GO:0031625 ubiquitin protein ligase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.