Domain

Heat shock protein beta-7, ACD domain (IPR037885)

Short name: ACD_HspB7

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp).

Small Hsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits [PMID: 11875128]. HspB7 is a 25 kDa protein, preferentially expressed in heart and skeletal muscle [PMID: 10593960]. It is essential for fetal heart development by modulating actin filament assembly [PMID: 29078393]. It binds the cytoskeleton protein alpha-filamin (also known as actin-binding protein 280) [PMID: 21045566]. The expression of HspB7 is increased during rat muscle aging [PMID: 17761354]. As the human gene encoding HspB7 is mapped to chromosome 1p36.23-p34.3 it is a positional candidate for several dystrophies and myopathies [PMID: 21461572].

GO terms

Biological Process

GO:0007507 heart development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD