Spp1/CFP1 (IPR037869)

Short name: Spp1/CFP1

Overlapping homologous superfamilies


Family relationships



Spp1 is a component of the COMPASS (Set1C) complex [PMID: 11687631]. It promotes meiotic DNA double-strand break formation in promoters by tethering histone H3K4 methylation sites to chromosome axes [PMID: 23246437]. This entry also includes CXXC-type zinc finger protein 1 (also known as CFP1) from animals [PMID: 21407193].

CXXC-type zinc finger protein 1 (CXXC1 or CFP1) is a component of the SETD1 histone H3K4 methyltransferase complex. CXXC1 directs the complex to a chromatin region via its CXXC zinc finger with a specificity for a CpG unmethylated motif, particularly CpGG [PMID: 21407193,PMID: 10688657].

The COMPASS (Complex Proteins Associated with Set1 or Set1C) is the yeast homologue of the human MLL complex, which is required for mono-, di-, and trimethylation of lysine 4 of histone H3 [PMID: 16168379]. It is required in telomeric transcriptional silencing [PMID: 11805083]. The complex consists of Set1, Bre2, Spp1, Sdc1, Shg1, Swd1, Swd2, and Swd3 [PMID: 11742990,PMID: 11687631].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0048188 Set1C/COMPASS complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.