ARAP, RhoGAP domain (IPR037858)

Short name: RhoGAP_ARAP

Overlapping homologous superfamilies

Domain relationships


This entry represenst a RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) are dual GTPase activating proteins (GAPs) for Arf and Rho family GTPases, and contain, besides the Rho-GAP domain, an Arf-GAP, ankyrin repeat ras-associating, and PH domains. Since their Arf-GAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling [PMID: 11804590, PMID: 11050434, PMID: 12015138, PMID: 15296756].

Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude [PMID: 9631293, PMID: 8193544, PMID: 7871593].

GO terms

Biological Process

GO:0043547 positive regulation of GTPase activity

Molecular Function

GO:0005096 GTPase activator activity
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.