Domain

SNX27, atypical FERM-like domain (IPR037827)

Short name: SNX27_FERM-like_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Sorting nexin-27(SNX27) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides [PMID: 16243015]. SNX27 also possesses an PDZ (DHR) domain, a Ras-associating domain and a FERM-like domain with an atypical tertiary structure [PMID: 21512128].

SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus [PMID: 20733053]. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [PMID: 23563491], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes [PMID: 20733053].

This entry represents the FERM-like domain of SNX27. This domain binds PtdInsPs in a manner that is distinct to that of distantly related FERM, pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains [PMID: 25472716].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0032266 phosphatidylinositol-3-phosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD