Ubiquitin carboxyl-terminal hydrolase 8 (IPR037798)

Short name: UBP8

Overlapping homologous superfamilies

Family relationships



This entry includes the ubiquitin carboxyl-terminal hydrolases 8 (UBP8; from Saccharomyces cerevisiae; MEROPS identifier C19.087), 11 (UPB11; from Schizosaccharomyces pombe; MEROPS identifier C19.A63) and nonstop (from Drosophila melanogaster; MEROPS identifier C19.095). UBP8 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK [PMID: 14660634]. In SAGA and SLIK, UBP8 deubiquitinates histone H2B and this regulates transcription [PMID: 14660634]. UBP8 has a zinc-binding domain with which it associates with the SAGA complex via the Sgf11 protein [PMID: 15657441]. Nonstop performs the same function in the Drosophila SAGA complex [PMID: 18188155].

The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B [PMID: 15647753]. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 [PMID: 9674425]. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [PMID: 25216679].

SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [PMID: 15647753,PMID: 12446794].

GO terms

Biological Process

GO:0016578 histone deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.